Abstract
AIM: We aimed to assess the resistance rates of antimicrobial-resistant, in bacterial pathogens of epidemiological importance in 47 Mexican centers.
MATERIAL AND METHODS: In this retrospective study, we included a stratified sample of 47 centers, covering 20 Mexican states. Selected isolates considered as potential causatives of disease collected over a 6-month period were included. Laboratories employed their usual methods to perform microbiological studies. The results were deposited into a database and analyzed with the WHONET 5.6 software.
RESULTS: In this 6-month study, a total of 22,943 strains were included. Regarding Gram-negatives, carbapenem resistance was detected in ≤ 3% in Escherichia coli, 12.5% in Klebsiella sp. and Enterobacter sp., and up to 40% in Pseudomonas aeruginosa; in the latter, the resistance rate for piperacillin-tazobactam (TZP) was as high as 19.1%. In Acinetobacter sp., resistance rates for cefepime, ciprofloxacin, meropenem, and TZP were higher than 50%. Regarding Gram-positives, methicillin resistance in Staphylococcus aureus (MRSA) was as high as 21.4%, and vancomycin (VAN) resistance reached up to 21% in Enterococcus faecium. Acinetobacter sp. presented the highest multidrug resistance (53%) followed by Klebsiella sp. (22.6%) and E. coli (19.4%).
CONCLUSION: The multidrug resistance of Acinetobacter sp., Klebsiella sp. and E. coli and the carbapenem resistance in specific groups of enterobacteria deserve special attention in Mexico. Vancomycin-resistant enterococci (VRE) and MRSA are common in our hospitals. Our results present valuable information for the implementation of measures to control drug resistance.
| Original language | English |
|---|---|
| Article number | e0209865 |
| Pages (from-to) | e0209865 |
| Journal | PLoS One |
| Volume | 14 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Mar 2019 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)
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A snapshot of antimicrobial resistance in Mexico. Results from 47 centers from 20 states during a six-month period. / Garza-González, Elvira; Morfín-Otero, Rayo; Mendoza-Olazarán, Soraya; Bocanegra-Ibarias, Paola; Flores-Treviño, Samantha; Rodríguez-Noriega, Eduardo; Ponce-de-León, Alfredo; Sanchez-Francia, Domingo; Franco-Cendejas, Rafael; Arroyo-Escalante, Sara; Velázquez-Acosta, Consuelo; Rojas-Larios, Fabián; Quintanilla, Luis J; Maldonado-Anicacio, Joyarit Y; Martínez-Miranda, Rafael; Ostos-Cantú, Heidy L; Gomez-Choel, Abraham; Jaime-Sanchez, Juan L; Avilés-Benítez, Laura K; Feliciano-Guzmán, José M; Peña-López, Cynthia D; Couoh-May, Carlos A; Molina-Jaimes, Aaron; Vázquez-Narvaez, Elda G; Rincón-Zuno, Joaquín; Rivera-Garay, Raúl; Galindo-Espinoza, Aurelio; Martínez-Ramirez, Andrés; Mora, Javier P; Corte-Rojas, Reyna E; López-Ovilla, Ismelda; Monroy-Colin, Víctor A; Barajas-Magallón, Juan M; Morales-De-la-Peña, Cecilia T; Aguirre-Burciaga, Efrén; Coronado-Ramírez, Mabel; Rosales-García, Alina A; Ayala-Tarín, María-de-J; Sida-Rodríguez, Silvia; Pérez-Vega, Bertha A; Navarro-Rodríguez, América; Juárez-Velázquez, Gloria E; Cetina-Umaña, Carlos Miguel; Mena-Ramírez, Juan P; Canizales-Oviedo, Jorge; Moreno-Méndez, Martha Irene; Romero-Romero, Daniel; Arévalo-Mejía, Alejandra; Cobos-Canul, Dulce Isabel; Aguilar-Orozco, Gilberto; Silva-Sánchez, Jesús; Camacho-Ortiz, Adrián.
In: PLoS One, Vol. 14, No. 3, e0209865, 01.03.2019, p. e0209865.Research output: Contribution to journal › Article
TY - JOUR
T1 - A snapshot of antimicrobial resistance in Mexico. Results from 47 centers from 20 states during a six-month period
AU - Garza-González, Elvira
AU - Morfín-Otero, Rayo
AU - Mendoza-Olazarán, Soraya
AU - Bocanegra-Ibarias, Paola
AU - Flores-Treviño, Samantha
AU - Rodríguez-Noriega, Eduardo
AU - Ponce-de-León, Alfredo
AU - Sanchez-Francia, Domingo
AU - Franco-Cendejas, Rafael
AU - Arroyo-Escalante, Sara
AU - Velázquez-Acosta, Consuelo
AU - Rojas-Larios, Fabián
AU - Quintanilla, Luis J
AU - Maldonado-Anicacio, Joyarit Y
AU - Martínez-Miranda, Rafael
AU - Ostos-Cantú, Heidy L
AU - Gomez-Choel, Abraham
AU - Jaime-Sanchez, Juan L
AU - Avilés-Benítez, Laura K
AU - Feliciano-Guzmán, José M
AU - Peña-López, Cynthia D
AU - Couoh-May, Carlos A
AU - Molina-Jaimes, Aaron
AU - Vázquez-Narvaez, Elda G
AU - Rincón-Zuno, Joaquín
AU - Rivera-Garay, Raúl
AU - Galindo-Espinoza, Aurelio
AU - Martínez-Ramirez, Andrés
AU - Mora, Javier P
AU - Corte-Rojas, Reyna E
AU - López-Ovilla, Ismelda
AU - Monroy-Colin, Víctor A
AU - Barajas-Magallón, Juan M
AU - Morales-De-la-Peña, Cecilia T
AU - Aguirre-Burciaga, Efrén
AU - Coronado-Ramírez, Mabel
AU - Rosales-García, Alina A
AU - Ayala-Tarín, María-de-J
AU - Sida-Rodríguez, Silvia
AU - Pérez-Vega, Bertha A
AU - Navarro-Rodríguez, América
AU - Juárez-Velázquez, Gloria E
AU - Cetina-Umaña, Carlos Miguel
AU - Mena-Ramírez, Juan P
AU - Canizales-Oviedo, Jorge
AU - Moreno-Méndez, Martha Irene
AU - Romero-Romero, Daniel
AU - Arévalo-Mejía, Alejandra
AU - Cobos-Canul, Dulce Isabel
AU - Aguilar-Orozco, Gilberto
AU - Silva-Sánchez, Jesús
AU - Camacho-Ortiz, Adrián
PY - 2019/3/1
Y1 - 2019/3/1
N2 - AIM: We aimed to assess the resistance rates of antimicrobial-resistant, in bacterial pathogens of epidemiological importance in 47 Mexican centers.MATERIAL AND METHODS: In this retrospective study, we included a stratified sample of 47 centers, covering 20 Mexican states. Selected isolates considered as potential causatives of disease collected over a 6-month period were included. Laboratories employed their usual methods to perform microbiological studies. The results were deposited into a database and analyzed with the WHONET 5.6 software.RESULTS: In this 6-month study, a total of 22,943 strains were included. Regarding Gram-negatives, carbapenem resistance was detected in ≤ 3% in Escherichia coli, 12.5% in Klebsiella sp. and Enterobacter sp., and up to 40% in Pseudomonas aeruginosa; in the latter, the resistance rate for piperacillin-tazobactam (TZP) was as high as 19.1%. In Acinetobacter sp., resistance rates for cefepime, ciprofloxacin, meropenem, and TZP were higher than 50%. Regarding Gram-positives, methicillin resistance in Staphylococcus aureus (MRSA) was as high as 21.4%, and vancomycin (VAN) resistance reached up to 21% in Enterococcus faecium. Acinetobacter sp. presented the highest multidrug resistance (53%) followed by Klebsiella sp. (22.6%) and E. coli (19.4%).CONCLUSION: The multidrug resistance of Acinetobacter sp., Klebsiella sp. and E. coli and the carbapenem resistance in specific groups of enterobacteria deserve special attention in Mexico. Vancomycin-resistant enterococci (VRE) and MRSA are common in our hospitals. Our results present valuable information for the implementation of measures to control drug resistance.
AB - AIM: We aimed to assess the resistance rates of antimicrobial-resistant, in bacterial pathogens of epidemiological importance in 47 Mexican centers.MATERIAL AND METHODS: In this retrospective study, we included a stratified sample of 47 centers, covering 20 Mexican states. Selected isolates considered as potential causatives of disease collected over a 6-month period were included. Laboratories employed their usual methods to perform microbiological studies. The results were deposited into a database and analyzed with the WHONET 5.6 software.RESULTS: In this 6-month study, a total of 22,943 strains were included. Regarding Gram-negatives, carbapenem resistance was detected in ≤ 3% in Escherichia coli, 12.5% in Klebsiella sp. and Enterobacter sp., and up to 40% in Pseudomonas aeruginosa; in the latter, the resistance rate for piperacillin-tazobactam (TZP) was as high as 19.1%. In Acinetobacter sp., resistance rates for cefepime, ciprofloxacin, meropenem, and TZP were higher than 50%. Regarding Gram-positives, methicillin resistance in Staphylococcus aureus (MRSA) was as high as 21.4%, and vancomycin (VAN) resistance reached up to 21% in Enterococcus faecium. Acinetobacter sp. presented the highest multidrug resistance (53%) followed by Klebsiella sp. (22.6%) and E. coli (19.4%).CONCLUSION: The multidrug resistance of Acinetobacter sp., Klebsiella sp. and E. coli and the carbapenem resistance in specific groups of enterobacteria deserve special attention in Mexico. Vancomycin-resistant enterococci (VRE) and MRSA are common in our hospitals. Our results present valuable information for the implementation of measures to control drug resistance.
UR - http://www.scopus.com/inward/record.url?scp=85063438969&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063438969&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0209865
DO - 10.1371/journal.pone.0209865
M3 - Article
C2 - 30913243
VL - 14
SP - e0209865
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 3
M1 - e0209865
ER -