A snapshot of antimicrobial resistance in Mexico. Results from 47 centers from 20 states during a six-month period

Elvira Garza-González; Rayo Morfín-Otero; Soraya Mendoza-Olazarán; Paola Bocanegra-Ibarias; Samantha Flores-Treviño; Eduardo Rodríguez-Noriega; Alfredo Ponce-de-León; Domingo Sanchez-Francia; Rafael Franco-Cendejas; Sara Arroyo-Escalante; Consuelo Velázquez-Acosta; Fabián Rojas-Larios; Luis J Quintanilla; Joyarit Y Maldonado-Anicacio; Rafael Martínez-Miranda; Heidy L Ostos-Cantú; Abraham Gomez-Choel; Juan L Jaime-Sanchez; Laura K Avilés-Benítez; José M Feliciano-Guzmán; Cynthia D Peña-López; Carlos A Couoh-May; Aaron Molina-Jaimes; Elda G Vázquez-Narvaez; Joaquín Rincón-Zuno; Raúl Rivera-Garay; Aurelio Galindo-Espinoza; Andrés Martínez-Ramirez; Javier P Mora; Reyna E Corte-Rojas; Ismelda López-Ovilla; Víctor A Monroy-Colin; Juan M Barajas-Magallón; Cecilia T Morales-De-la-Peña; Efrén Aguirre-Burciaga; Mabel Coronado-Ramírez; Alina A Rosales-García; María-de-J Ayala-Tarín; Silvia Sida-Rodríguez; Bertha A Pérez-Vega; América Navarro-Rodríguez; Gloria E Juárez-Velázquez; Carlos Miguel Cetina-Umaña; Juan P Mena-Ramírez; Jorge Canizales-Oviedo; Martha Irene Moreno-Méndez; Daniel Romero-Romero; Alejandra Arévalo-Mejía; Dulce Isabel Cobos-Canul; Gilberto Aguilar-Orozco; Jesús Silva-Sánchez; Adrián Camacho-Ortiz

doi:10.1371/journal.pone.0209865

A snapshot of antimicrobial resistance in Mexico. Results from 47 centers from 20 states during a six-month period

Elvira Garza-González, Rayo Morfín-Otero, Soraya Mendoza-Olazarán, Paola Bocanegra-Ibarias, Samantha Flores-Treviño, Eduardo Rodríguez-Noriega, Alfredo Ponce-de-León, Domingo Sanchez-Francia, Rafael Franco-Cendejas, Sara Arroyo-Escalante, Consuelo Velázquez-Acosta, Fabián Rojas-Larios, Luis J Quintanilla, Joyarit Y Maldonado-Anicacio, Rafael Martínez-Miranda, Heidy L Ostos-Cantú, Abraham Gomez-Choel, Juan L Jaime-Sanchez, Laura K Avilés-Benítez, José M Feliciano-GuzmánCynthia D Peña-López, Carlos A Couoh-May, Aaron Molina-Jaimes, Elda G Vázquez-Narvaez, Joaquín Rincón-Zuno, Raúl Rivera-Garay, Aurelio Galindo-Espinoza, Andrés Martínez-Ramirez, Javier P Mora, Reyna E Corte-Rojas, Ismelda López-Ovilla, Víctor A Monroy-Colin, Juan M Barajas-Magallón, Cecilia T Morales-De-la-Peña, Efrén Aguirre-Burciaga, Mabel Coronado-Ramírez, Alina A Rosales-García, María-de-J Ayala-Tarín, Silvia Sida-Rodríguez, Bertha A Pérez-Vega, América Navarro-Rodríguez, Gloria E Juárez-Velázquez, Carlos Miguel Cetina-Umaña, Juan P Mena-Ramírez, Jorge Canizales-Oviedo, Martha Irene Moreno-Méndez, Daniel Romero-Romero, Alejandra Arévalo-Mejía, Dulce Isabel Cobos-Canul, Gilberto Aguilar-Orozco, Jesús Silva-Sánchez, Adrián Camacho-Ortiz

Research output: Contribution to journal › Article › peer-review

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Abstract

AIM: We aimed to assess the resistance rates of antimicrobial-resistant, in bacterial pathogens of epidemiological importance in 47 Mexican centers.

MATERIAL AND METHODS: In this retrospective study, we included a stratified sample of 47 centers, covering 20 Mexican states. Selected isolates considered as potential causatives of disease collected over a 6-month period were included. Laboratories employed their usual methods to perform microbiological studies. The results were deposited into a database and analyzed with the WHONET 5.6 software.

RESULTS: In this 6-month study, a total of 22,943 strains were included. Regarding Gram-negatives, carbapenem resistance was detected in ≤ 3% in Escherichia coli, 12.5% in Klebsiella sp. and Enterobacter sp., and up to 40% in Pseudomonas aeruginosa; in the latter, the resistance rate for piperacillin-tazobactam (TZP) was as high as 19.1%. In Acinetobacter sp., resistance rates for cefepime, ciprofloxacin, meropenem, and TZP were higher than 50%. Regarding Gram-positives, methicillin resistance in Staphylococcus aureus (MRSA) was as high as 21.4%, and vancomycin (VAN) resistance reached up to 21% in Enterococcus faecium. Acinetobacter sp. presented the highest multidrug resistance (53%) followed by Klebsiella sp. (22.6%) and E. coli (19.4%).

CONCLUSION: The multidrug resistance of Acinetobacter sp., Klebsiella sp. and E. coli and the carbapenem resistance in specific groups of enterobacteria deserve special attention in Mexico. Vancomycin-resistant enterococci (VRE) and MRSA are common in our hospitals. Our results present valuable information for the implementation of measures to control drug resistance.

Original language	English
Article number	e0209865
Pages (from-to)	e0209865
Journal	PLoS One
Volume	14
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0209865
Publication status	Published - 26 Mar 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Garza-González et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1371/journal.pone.0209865

Cite this

Garza-González, E., Morfín-Otero, R., Mendoza-Olazarán, S., Bocanegra-Ibarias, P., Flores-Treviño, S., Rodríguez-Noriega, E., Ponce-de-León, A., Sanchez-Francia, D., Franco-Cendejas, R., Arroyo-Escalante, S., Velázquez-Acosta, C., Rojas-Larios, F., Quintanilla, L. J., Maldonado-Anicacio, J. Y., Martínez-Miranda, R., Ostos-Cantú, H. L., Gomez-Choel, A., Jaime-Sanchez, J. L., Avilés-Benítez, L. K., ... Camacho-Ortiz, A. (2019). A snapshot of antimicrobial resistance in Mexico. Results from 47 centers from 20 states during a six-month period. PLoS One, 14(3), e0209865. Article e0209865. https://doi.org/10.1371/journal.pone.0209865

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title = "A snapshot of antimicrobial resistance in Mexico. Results from 47 centers from 20 states during a six-month period",

abstract = "AIM: We aimed to assess the resistance rates of antimicrobial-resistant, in bacterial pathogens of epidemiological importance in 47 Mexican centers.MATERIAL AND METHODS: In this retrospective study, we included a stratified sample of 47 centers, covering 20 Mexican states. Selected isolates considered as potential causatives of disease collected over a 6-month period were included. Laboratories employed their usual methods to perform microbiological studies. The results were deposited into a database and analyzed with the WHONET 5.6 software.RESULTS: In this 6-month study, a total of 22,943 strains were included. Regarding Gram-negatives, carbapenem resistance was detected in ≤ 3% in Escherichia coli, 12.5% in Klebsiella sp. and Enterobacter sp., and up to 40% in Pseudomonas aeruginosa; in the latter, the resistance rate for piperacillin-tazobactam (TZP) was as high as 19.1%. In Acinetobacter sp., resistance rates for cefepime, ciprofloxacin, meropenem, and TZP were higher than 50%. Regarding Gram-positives, methicillin resistance in Staphylococcus aureus (MRSA) was as high as 21.4%, and vancomycin (VAN) resistance reached up to 21% in Enterococcus faecium. Acinetobacter sp. presented the highest multidrug resistance (53%) followed by Klebsiella sp. (22.6%) and E. coli (19.4%).CONCLUSION: The multidrug resistance of Acinetobacter sp., Klebsiella sp. and E. coli and the carbapenem resistance in specific groups of enterobacteria deserve special attention in Mexico. Vancomycin-resistant enterococci (VRE) and MRSA are common in our hospitals. Our results present valuable information for the implementation of measures to control drug resistance.",

author = "Elvira Garza-Gonz{\'a}lez and Rayo Morf{\'i}n-Otero and Soraya Mendoza-Olazar{\'a}n and Paola Bocanegra-Ibarias and Samantha Flores-Trevi{\~n}o and Eduardo Rodr{\'i}guez-Noriega and Alfredo Ponce-de-Le{\'o}n and Domingo Sanchez-Francia and Rafael Franco-Cendejas and Sara Arroyo-Escalante and Consuelo Vel{\'a}zquez-Acosta and Fabi{\'a}n Rojas-Larios and Quintanilla, {Luis J} and Maldonado-Anicacio, {Joyarit Y} and Rafael Mart{\'i}nez-Miranda and Ostos-Cant{\'u}, {Heidy L} and Abraham Gomez-Choel and Jaime-Sanchez, {Juan L} and Avil{\'e}s-Ben{\'i}tez, {Laura K} and Feliciano-Guzm{\'a}n, {Jos{\'e} M} and Pe{\~n}a-L{\'o}pez, {Cynthia D} and Couoh-May, {Carlos A} and Aaron Molina-Jaimes and V{\'a}zquez-Narvaez, {Elda G} and Joaqu{\'i}n Rinc{\'o}n-Zuno and Ra{\'u}l Rivera-Garay and Aurelio Galindo-Espinoza and Andr{\'e}s Mart{\'i}nez-Ramirez and Mora, {Javier P} and Corte-Rojas, {Reyna E} and Ismelda L{\'o}pez-Ovilla and Monroy-Colin, {V{\'i}ctor A} and Barajas-Magall{\'o}n, {Juan M} and Morales-De-la-Pe{\~n}a, {Cecilia T} and Efr{\'e}n Aguirre-Burciaga and Mabel Coronado-Ram{\'i}rez and Rosales-Garc{\'i}a, {Alina A} and Mar{\'i}a-de-J Ayala-Tar{\'i}n and Silvia Sida-Rodr{\'i}guez and P{\'e}rez-Vega, {Bertha A} and Am{\'e}rica Navarro-Rodr{\'i}guez and Ju{\'a}rez-Vel{\'a}zquez, {Gloria E} and Cetina-Uma{\~n}a, {Carlos Miguel} and Mena-Ram{\'i}rez, {Juan P} and Jorge Canizales-Oviedo and Moreno-M{\'e}ndez, {Martha Irene} and Daniel Romero-Romero and Alejandra Ar{\'e}valo-Mej{\'i}a and Cobos-Canul, {Dulce Isabel} and Gilberto Aguilar-Orozco and Jes{\'u}s Silva-S{\'a}nchez and Adri{\'a}n Camacho-Ortiz",

note = "Publisher Copyright: {\textcopyright} 2019 Garza-Gonz{\'a}lez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2019",

month = mar,

day = "26",

doi = "10.1371/journal.pone.0209865",

language = "English",

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pages = "e0209865",

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Garza-González, E, Morfín-Otero, R, Mendoza-Olazarán, S, Bocanegra-Ibarias, P, Flores-Treviño, S, Rodríguez-Noriega, E, Ponce-de-León, A, Sanchez-Francia, D, Franco-Cendejas, R, Arroyo-Escalante, S, Velázquez-Acosta, C, Rojas-Larios, F, Quintanilla, LJ, Maldonado-Anicacio, JY, Martínez-Miranda, R, Ostos-Cantú, HL, Gomez-Choel, A, Jaime-Sanchez, JL, Avilés-Benítez, LK, Feliciano-Guzmán, JM, Peña-López, CD, Couoh-May, CA, Molina-Jaimes, A, Vázquez-Narvaez, EG, Rincón-Zuno, J, Rivera-Garay, R, Galindo-Espinoza, A, Martínez-Ramirez, A, Mora, JP, Corte-Rojas, RE, López-Ovilla, I, Monroy-Colin, VA, Barajas-Magallón, JM, Morales-De-la-Peña, CT, Aguirre-Burciaga, E, Coronado-Ramírez, M, Rosales-García, AA, Ayala-Tarín, M-J, Sida-Rodríguez, S, Pérez-Vega, BA, Navarro-Rodríguez, A, Juárez-Velázquez, GE, Cetina-Umaña, CM, Mena-Ramírez, JP, Canizales-Oviedo, J, Moreno-Méndez, MI, Romero-Romero, D, Arévalo-Mejía, A, Cobos-Canul, DI, Aguilar-Orozco, G, Silva-Sánchez, J & Camacho-Ortiz, A 2019, 'A snapshot of antimicrobial resistance in Mexico. Results from 47 centers from 20 states during a six-month period', PLoS One, vol. 14, no. 3, e0209865, pp. e0209865. https://doi.org/10.1371/journal.pone.0209865

TY - JOUR

T1 - A snapshot of antimicrobial resistance in Mexico. Results from 47 centers from 20 states during a six-month period

AU - Garza-González, Elvira

AU - Morfín-Otero, Rayo

AU - Mendoza-Olazarán, Soraya

AU - Bocanegra-Ibarias, Paola

AU - Flores-Treviño, Samantha

AU - Rodríguez-Noriega, Eduardo

AU - Ponce-de-León, Alfredo

AU - Sanchez-Francia, Domingo

AU - Franco-Cendejas, Rafael

AU - Arroyo-Escalante, Sara

AU - Velázquez-Acosta, Consuelo

AU - Rojas-Larios, Fabián

AU - Quintanilla, Luis J

AU - Maldonado-Anicacio, Joyarit Y

AU - Martínez-Miranda, Rafael

AU - Ostos-Cantú, Heidy L

AU - Gomez-Choel, Abraham

AU - Jaime-Sanchez, Juan L

AU - Avilés-Benítez, Laura K

AU - Feliciano-Guzmán, José M

AU - Peña-López, Cynthia D

AU - Couoh-May, Carlos A

AU - Molina-Jaimes, Aaron

AU - Vázquez-Narvaez, Elda G

AU - Rincón-Zuno, Joaquín

AU - Rivera-Garay, Raúl

AU - Galindo-Espinoza, Aurelio

AU - Martínez-Ramirez, Andrés

AU - Mora, Javier P

AU - Corte-Rojas, Reyna E

AU - López-Ovilla, Ismelda

AU - Monroy-Colin, Víctor A

AU - Barajas-Magallón, Juan M

AU - Morales-De-la-Peña, Cecilia T

AU - Aguirre-Burciaga, Efrén

AU - Coronado-Ramírez, Mabel

AU - Rosales-García, Alina A

AU - Ayala-Tarín, María-de-J

AU - Sida-Rodríguez, Silvia

AU - Pérez-Vega, Bertha A

AU - Navarro-Rodríguez, América

AU - Juárez-Velázquez, Gloria E

AU - Cetina-Umaña, Carlos Miguel

AU - Mena-Ramírez, Juan P

AU - Canizales-Oviedo, Jorge

AU - Moreno-Méndez, Martha Irene

AU - Romero-Romero, Daniel

AU - Arévalo-Mejía, Alejandra

AU - Cobos-Canul, Dulce Isabel

AU - Aguilar-Orozco, Gilberto

AU - Silva-Sánchez, Jesús

AU - Camacho-Ortiz, Adrián

N1 - Publisher Copyright: © 2019 Garza-González et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2019/3/26

Y1 - 2019/3/26

N2 - AIM: We aimed to assess the resistance rates of antimicrobial-resistant, in bacterial pathogens of epidemiological importance in 47 Mexican centers.MATERIAL AND METHODS: In this retrospective study, we included a stratified sample of 47 centers, covering 20 Mexican states. Selected isolates considered as potential causatives of disease collected over a 6-month period were included. Laboratories employed their usual methods to perform microbiological studies. The results were deposited into a database and analyzed with the WHONET 5.6 software.RESULTS: In this 6-month study, a total of 22,943 strains were included. Regarding Gram-negatives, carbapenem resistance was detected in ≤ 3% in Escherichia coli, 12.5% in Klebsiella sp. and Enterobacter sp., and up to 40% in Pseudomonas aeruginosa; in the latter, the resistance rate for piperacillin-tazobactam (TZP) was as high as 19.1%. In Acinetobacter sp., resistance rates for cefepime, ciprofloxacin, meropenem, and TZP were higher than 50%. Regarding Gram-positives, methicillin resistance in Staphylococcus aureus (MRSA) was as high as 21.4%, and vancomycin (VAN) resistance reached up to 21% in Enterococcus faecium. Acinetobacter sp. presented the highest multidrug resistance (53%) followed by Klebsiella sp. (22.6%) and E. coli (19.4%).CONCLUSION: The multidrug resistance of Acinetobacter sp., Klebsiella sp. and E. coli and the carbapenem resistance in specific groups of enterobacteria deserve special attention in Mexico. Vancomycin-resistant enterococci (VRE) and MRSA are common in our hospitals. Our results present valuable information for the implementation of measures to control drug resistance.

AB - AIM: We aimed to assess the resistance rates of antimicrobial-resistant, in bacterial pathogens of epidemiological importance in 47 Mexican centers.MATERIAL AND METHODS: In this retrospective study, we included a stratified sample of 47 centers, covering 20 Mexican states. Selected isolates considered as potential causatives of disease collected over a 6-month period were included. Laboratories employed their usual methods to perform microbiological studies. The results were deposited into a database and analyzed with the WHONET 5.6 software.RESULTS: In this 6-month study, a total of 22,943 strains were included. Regarding Gram-negatives, carbapenem resistance was detected in ≤ 3% in Escherichia coli, 12.5% in Klebsiella sp. and Enterobacter sp., and up to 40% in Pseudomonas aeruginosa; in the latter, the resistance rate for piperacillin-tazobactam (TZP) was as high as 19.1%. In Acinetobacter sp., resistance rates for cefepime, ciprofloxacin, meropenem, and TZP were higher than 50%. Regarding Gram-positives, methicillin resistance in Staphylococcus aureus (MRSA) was as high as 21.4%, and vancomycin (VAN) resistance reached up to 21% in Enterococcus faecium. Acinetobacter sp. presented the highest multidrug resistance (53%) followed by Klebsiella sp. (22.6%) and E. coli (19.4%).CONCLUSION: The multidrug resistance of Acinetobacter sp., Klebsiella sp. and E. coli and the carbapenem resistance in specific groups of enterobacteria deserve special attention in Mexico. Vancomycin-resistant enterococci (VRE) and MRSA are common in our hospitals. Our results present valuable information for the implementation of measures to control drug resistance.

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UR - http://www.mendeley.com/research/snapshot-antimicrobial-resistance-mexico-results-47-centers-20-states-during-sixmonth-period

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DO - 10.1371/journal.pone.0209865

M3 - Article

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SN - 1932-6203

VL - 14

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JO - PLoS One

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A snapshot of antimicrobial resistance in Mexico. Results from 47 centers from 20 states during a six-month period

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