A snapshot of antimicrobial resistance in Mexico. Results from 47 centers from 20 states during a six-month period

Elvira Garza-González, Rayo Morfín-Otero, Soraya Mendoza-Olazarán, Paola Bocanegra-Ibarias, Samantha Flores-Treviño, Eduardo Rodríguez-Noriega, Alfredo Ponce-de-León, Domingo Sanchez-Francia, Rafael Franco-Cendejas, Sara Arroyo-Escalante, Consuelo Velázquez-Acosta, Fabián Rojas-Larios, Luis J Quintanilla, Joyarit Y Maldonado-Anicacio, Rafael Martínez-Miranda, Heidy L Ostos-Cantú, Abraham Gomez-Choel, Juan L Jaime-Sanchez, Laura K Avilés-Benítez, José M Feliciano-GuzmánCynthia D Peña-López, Carlos A Couoh-May, Aaron Molina-Jaimes, Elda G Vázquez-Narvaez, Joaquín Rincón-Zuno, Raúl Rivera-Garay, Aurelio Galindo-Espinoza, Andrés Martínez-Ramirez, Javier P Mora, Reyna E Corte-Rojas, Ismelda López-Ovilla, Víctor A Monroy-Colin, Juan M Barajas-Magallón, Cecilia T Morales-De-la-Peña, Efrén Aguirre-Burciaga, Mabel Coronado-Ramírez, Alina A Rosales-García, María-de-J Ayala-Tarín, Silvia Sida-Rodríguez, Bertha A Pérez-Vega, América Navarro-Rodríguez, Gloria E Juárez-Velázquez, Carlos Miguel Cetina-Umaña, Juan P Mena-Ramírez, Jorge Canizales-Oviedo, Martha Irene Moreno-Méndez, Daniel Romero-Romero, Alejandra Arévalo-Mejía, Dulce Isabel Cobos-Canul, Gilberto Aguilar-Orozco, Jesús Silva-Sánchez, Adrián Camacho-Ortiz

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Abstract

AIM: We aimed to assess the resistance rates of antimicrobial-resistant, in bacterial pathogens of epidemiological importance in 47 Mexican centers.

MATERIAL AND METHODS: In this retrospective study, we included a stratified sample of 47 centers, covering 20 Mexican states. Selected isolates considered as potential causatives of disease collected over a 6-month period were included. Laboratories employed their usual methods to perform microbiological studies. The results were deposited into a database and analyzed with the WHONET 5.6 software.

RESULTS: In this 6-month study, a total of 22,943 strains were included. Regarding Gram-negatives, carbapenem resistance was detected in ≤ 3% in Escherichia coli, 12.5% in Klebsiella sp. and Enterobacter sp., and up to 40% in Pseudomonas aeruginosa; in the latter, the resistance rate for piperacillin-tazobactam (TZP) was as high as 19.1%. In Acinetobacter sp., resistance rates for cefepime, ciprofloxacin, meropenem, and TZP were higher than 50%. Regarding Gram-positives, methicillin resistance in Staphylococcus aureus (MRSA) was as high as 21.4%, and vancomycin (VAN) resistance reached up to 21% in Enterococcus faecium. Acinetobacter sp. presented the highest multidrug resistance (53%) followed by Klebsiella sp. (22.6%) and E. coli (19.4%).

CONCLUSION: The multidrug resistance of Acinetobacter sp., Klebsiella sp. and E. coli and the carbapenem resistance in specific groups of enterobacteria deserve special attention in Mexico. Vancomycin-resistant enterococci (VRE) and MRSA are common in our hospitals. Our results present valuable information for the implementation of measures to control drug resistance.

Original languageEnglish
Article numbere0209865
Pages (from-to)e0209865
JournalPLoS One
Volume14
Issue number3
DOIs
Publication statusPublished - 1 Mar 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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    Garza-González, E., Morfín-Otero, R., Mendoza-Olazarán, S., Bocanegra-Ibarias, P., Flores-Treviño, S., Rodríguez-Noriega, E., Ponce-de-León, A., Sanchez-Francia, D., Franco-Cendejas, R., Arroyo-Escalante, S., Velázquez-Acosta, C., Rojas-Larios, F., Quintanilla, L. J., Maldonado-Anicacio, J. Y., Martínez-Miranda, R., Ostos-Cantú, H. L., Gomez-Choel, A., Jaime-Sanchez, J. L., Avilés-Benítez, L. K., ... Camacho-Ortiz, A. (2019). A snapshot of antimicrobial resistance in Mexico. Results from 47 centers from 20 states during a six-month period. PLoS One, 14(3), e0209865. [e0209865]. https://doi.org/10.1371/journal.pone.0209865