A Polyurethane Electrospun Membrane Loaded with Bismuth Lipophilic Nanoparticles (BisBAL NPs): Proliferation, Bactericidal, and Antitumor Properties, and Effects on MRSA and Human Breast Cancer Cells

Jesús Alejandro Torres-Betancourt; Rene Hernández-Delgadillo; Juan Valerio Cauich-Rodríguez; Diego Adrián Oliva-Rico; Juan Manuel Solis-Soto; Claudia María García-Cuellar; Yesennia Sánchez-Pérez; Nayely Pineda-Aguilar; Samantha Flores-Treviño; Irene Meester; Sergio Eduardo Nakagoshi-Cepeda; Katiushka Arevalo-Niño; María Argelia Akemi Nakagoshi-Cepeda; Claudio Cabral-Romero

doi:10.3390/jfb15100309

A Polyurethane Electrospun Membrane Loaded with Bismuth Lipophilic Nanoparticles (BisBAL NPs): Proliferation, Bactericidal, and Antitumor Properties, and Effects on MRSA and Human Breast Cancer Cells

Jesús Alejandro Torres-Betancourt, Rene Hernández-Delgadillo, Juan Valerio Cauich-Rodríguez, Diego Adrián Oliva-Rico, Juan Manuel Solis-Soto, Claudia María García-Cuellar, Yesennia Sánchez-Pérez, Nayely Pineda-Aguilar, Samantha Flores-Treviño, Irene Meester, Sergio Eduardo Nakagoshi-Cepeda, Katiushka Arevalo-Niño, María Argelia Akemi Nakagoshi-Cepeda, Claudio Cabral-Romero^*

^*Corresponding author for this work

Departamento Académico

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Electrospun membranes (EMs) have a wide range of applications, including use as local delivery systems. In this study, we manufactured a polyurethane Tecoflex™ EM loaded with bismuth-based lipophilic nanoparticles (Tecoflex™ EMs-BisBAL NPs). The physicochemical and mechanical characteristics, along with the antitumor and bactericidal effects, were evaluated using a breast cancer cell line and methicillin-susceptible and resistant Staphylococcus aureus (MRSA). Drug-free Tecoflex™ EMs and Tecoflex™ EMs-BisBAL NPs had similar fiber diameters of 4.65 ± 1.42 µm and 3.95 ± 1.32 µm, respectively. Drug-free Tecoflex™ EMs did not negatively impact a human fibroblast culture, indicating that the vehicle is biocompatible. Tecoflex™ EMs-BisBAL NPs increased 94% more in size than drug-free Tecoflex™ EMs, indicating that the BisBAL NPs enhanced hydration capacity. Tecoflex™ EMs-BisBAL NPs were highly bactericidal against both methicillin-susceptible S. aureus and MRSA clinical isolates, inhibiting their growth by 93.11% and 61.70%, respectively. Additionally, Tecoflex™ EMs-BisBAL NPs decreased the viability of MCF-7 tumor cells by 86% after 24 h exposure and 70.1% within 15 min. Regarding the mechanism of action of Tecoflex™ EMs-BisBAL NPs, it appears to disrupt the tumor cell membrane. In conclusion, Tecoflex™ EMs-BisBAL NPs constitute an innovative low-cost drug delivery system for human breast cancer and postoperative wound infections.

Original language	English
Article number	309
Journal	Journal of Functional Biomaterials
Volume	15
Issue number	10
DOIs	https://doi.org/10.3390/jfb15100309
Publication status	Published - Oct 2024

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Publisher Copyright:
© 2024 by the authors.

All Science Journal Classification (ASJC) codes

Biomaterials
Biomedical Engineering

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Torres-Betancourt, J. A., Hernández-Delgadillo, R., Cauich-Rodríguez, J. V., Oliva-Rico, D. A., Solis-Soto, J. M., García-Cuellar, C. M., Sánchez-Pérez, Y., Pineda-Aguilar, N., Flores-Treviño, S., Meester, I., Nakagoshi-Cepeda, S. E., Arevalo-Niño, K., Nakagoshi-Cepeda, M. A. A., & Cabral-Romero, C. (2024). A Polyurethane Electrospun Membrane Loaded with Bismuth Lipophilic Nanoparticles (BisBAL NPs): Proliferation, Bactericidal, and Antitumor Properties, and Effects on MRSA and Human Breast Cancer Cells. Journal of Functional Biomaterials, 15(10), Article 309. https://doi.org/10.3390/jfb15100309

Torres-Betancourt, Jesús Alejandro ; Hernández-Delgadillo, Rene ; Cauich-Rodríguez, Juan Valerio et al. / A Polyurethane Electrospun Membrane Loaded with Bismuth Lipophilic Nanoparticles (BisBAL NPs) : Proliferation, Bactericidal, and Antitumor Properties, and Effects on MRSA and Human Breast Cancer Cells. In: Journal of Functional Biomaterials. 2024 ; Vol. 15, No. 10.

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title = "A Polyurethane Electrospun Membrane Loaded with Bismuth Lipophilic Nanoparticles (BisBAL NPs): Proliferation, Bactericidal, and Antitumor Properties, and Effects on MRSA and Human Breast Cancer Cells",

abstract = "Electrospun membranes (EMs) have a wide range of applications, including use as local delivery systems. In this study, we manufactured a polyurethane Tecoflex{\texttrademark} EM loaded with bismuth-based lipophilic nanoparticles (Tecoflex{\texttrademark} EMs-BisBAL NPs). The physicochemical and mechanical characteristics, along with the antitumor and bactericidal effects, were evaluated using a breast cancer cell line and methicillin-susceptible and resistant Staphylococcus aureus (MRSA). Drug-free Tecoflex{\texttrademark} EMs and Tecoflex{\texttrademark} EMs-BisBAL NPs had similar fiber diameters of 4.65 ± 1.42 µm and 3.95 ± 1.32 µm, respectively. Drug-free Tecoflex{\texttrademark} EMs did not negatively impact a human fibroblast culture, indicating that the vehicle is biocompatible. Tecoflex{\texttrademark} EMs-BisBAL NPs increased 94% more in size than drug-free Tecoflex{\texttrademark} EMs, indicating that the BisBAL NPs enhanced hydration capacity. Tecoflex{\texttrademark} EMs-BisBAL NPs were highly bactericidal against both methicillin-susceptible S. aureus and MRSA clinical isolates, inhibiting their growth by 93.11% and 61.70%, respectively. Additionally, Tecoflex{\texttrademark} EMs-BisBAL NPs decreased the viability of MCF-7 tumor cells by 86% after 24 h exposure and 70.1% within 15 min. Regarding the mechanism of action of Tecoflex{\texttrademark} EMs-BisBAL NPs, it appears to disrupt the tumor cell membrane. In conclusion, Tecoflex{\texttrademark} EMs-BisBAL NPs constitute an innovative low-cost drug delivery system for human breast cancer and postoperative wound infections.",

author = "Torres-Betancourt, {Jes{\'u}s Alejandro} and Rene Hern{\'a}ndez-Delgadillo and Cauich-Rodr{\'i}guez, {Juan Valerio} and Oliva-Rico, {Diego Adri{\'a}n} and Solis-Soto, {Juan Manuel} and Garc{\'i}a-Cuellar, {Claudia Mar{\'i}a} and Yesennia S{\'a}nchez-P{\'e}rez and Nayely Pineda-Aguilar and Samantha Flores-Trevi{\~n}o and Irene Meester and Nakagoshi-Cepeda, {Sergio Eduardo} and Katiushka Arevalo-Ni{\~n}o and Nakagoshi-Cepeda, {Mar{\'i}a Argelia Akemi} and Claudio Cabral-Romero",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = oct,

doi = "10.3390/jfb15100309",

language = "English",

volume = "15",

journal = "Journal of Functional Biomaterials",

issn = "2079-4983",

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Torres-Betancourt, JA, Hernández-Delgadillo, R, Cauich-Rodríguez, JV, Oliva-Rico, DA, Solis-Soto, JM, García-Cuellar, CM, Sánchez-Pérez, Y, Pineda-Aguilar, N, Flores-Treviño, S, Meester, I, Nakagoshi-Cepeda, SE, Arevalo-Niño, K, Nakagoshi-Cepeda, MAA & Cabral-Romero, C 2024, 'A Polyurethane Electrospun Membrane Loaded with Bismuth Lipophilic Nanoparticles (BisBAL NPs): Proliferation, Bactericidal, and Antitumor Properties, and Effects on MRSA and Human Breast Cancer Cells', Journal of Functional Biomaterials, vol. 15, no. 10, 309. https://doi.org/10.3390/jfb15100309

A Polyurethane Electrospun Membrane Loaded with Bismuth Lipophilic Nanoparticles (BisBAL NPs): Proliferation, Bactericidal, and Antitumor Properties, and Effects on MRSA and Human Breast Cancer Cells. / Torres-Betancourt, Jesús Alejandro; Hernández-Delgadillo, Rene; Cauich-Rodríguez, Juan Valerio et al.
In: Journal of Functional Biomaterials, Vol. 15, No. 10, 309, 10.2024.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A Polyurethane Electrospun Membrane Loaded with Bismuth Lipophilic Nanoparticles (BisBAL NPs)

T2 - Proliferation, Bactericidal, and Antitumor Properties, and Effects on MRSA and Human Breast Cancer Cells

AU - Torres-Betancourt, Jesús Alejandro

AU - Hernández-Delgadillo, Rene

AU - Cauich-Rodríguez, Juan Valerio

AU - Oliva-Rico, Diego Adrián

AU - Solis-Soto, Juan Manuel

AU - García-Cuellar, Claudia María

AU - Sánchez-Pérez, Yesennia

AU - Pineda-Aguilar, Nayely

AU - Flores-Treviño, Samantha

AU - Meester, Irene

AU - Nakagoshi-Cepeda, Sergio Eduardo

AU - Arevalo-Niño, Katiushka

AU - Nakagoshi-Cepeda, María Argelia Akemi

AU - Cabral-Romero, Claudio

PY - 2024/10

Y1 - 2024/10

N2 - Electrospun membranes (EMs) have a wide range of applications, including use as local delivery systems. In this study, we manufactured a polyurethane Tecoflex™ EM loaded with bismuth-based lipophilic nanoparticles (Tecoflex™ EMs-BisBAL NPs). The physicochemical and mechanical characteristics, along with the antitumor and bactericidal effects, were evaluated using a breast cancer cell line and methicillin-susceptible and resistant Staphylococcus aureus (MRSA). Drug-free Tecoflex™ EMs and Tecoflex™ EMs-BisBAL NPs had similar fiber diameters of 4.65 ± 1.42 µm and 3.95 ± 1.32 µm, respectively. Drug-free Tecoflex™ EMs did not negatively impact a human fibroblast culture, indicating that the vehicle is biocompatible. Tecoflex™ EMs-BisBAL NPs increased 94% more in size than drug-free Tecoflex™ EMs, indicating that the BisBAL NPs enhanced hydration capacity. Tecoflex™ EMs-BisBAL NPs were highly bactericidal against both methicillin-susceptible S. aureus and MRSA clinical isolates, inhibiting their growth by 93.11% and 61.70%, respectively. Additionally, Tecoflex™ EMs-BisBAL NPs decreased the viability of MCF-7 tumor cells by 86% after 24 h exposure and 70.1% within 15 min. Regarding the mechanism of action of Tecoflex™ EMs-BisBAL NPs, it appears to disrupt the tumor cell membrane. In conclusion, Tecoflex™ EMs-BisBAL NPs constitute an innovative low-cost drug delivery system for human breast cancer and postoperative wound infections.

AB - Electrospun membranes (EMs) have a wide range of applications, including use as local delivery systems. In this study, we manufactured a polyurethane Tecoflex™ EM loaded with bismuth-based lipophilic nanoparticles (Tecoflex™ EMs-BisBAL NPs). The physicochemical and mechanical characteristics, along with the antitumor and bactericidal effects, were evaluated using a breast cancer cell line and methicillin-susceptible and resistant Staphylococcus aureus (MRSA). Drug-free Tecoflex™ EMs and Tecoflex™ EMs-BisBAL NPs had similar fiber diameters of 4.65 ± 1.42 µm and 3.95 ± 1.32 µm, respectively. Drug-free Tecoflex™ EMs did not negatively impact a human fibroblast culture, indicating that the vehicle is biocompatible. Tecoflex™ EMs-BisBAL NPs increased 94% more in size than drug-free Tecoflex™ EMs, indicating that the BisBAL NPs enhanced hydration capacity. Tecoflex™ EMs-BisBAL NPs were highly bactericidal against both methicillin-susceptible S. aureus and MRSA clinical isolates, inhibiting their growth by 93.11% and 61.70%, respectively. Additionally, Tecoflex™ EMs-BisBAL NPs decreased the viability of MCF-7 tumor cells by 86% after 24 h exposure and 70.1% within 15 min. Regarding the mechanism of action of Tecoflex™ EMs-BisBAL NPs, it appears to disrupt the tumor cell membrane. In conclusion, Tecoflex™ EMs-BisBAL NPs constitute an innovative low-cost drug delivery system for human breast cancer and postoperative wound infections.

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U2 - 10.3390/jfb15100309

DO - 10.3390/jfb15100309

M3 - Article

AN - SCOPUS:85207311312

SN - 2079-4983

VL - 15

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Torres-Betancourt JA, Hernández-Delgadillo R, Cauich-Rodríguez JV, Oliva-Rico DA, Solis-Soto JM, García-Cuellar CM et al. A Polyurethane Electrospun Membrane Loaded with Bismuth Lipophilic Nanoparticles (BisBAL NPs): Proliferation, Bactericidal, and Antitumor Properties, and Effects on MRSA and Human Breast Cancer Cells. Journal of Functional Biomaterials. 2024 Oct;15(10):309. doi: 10.3390/jfb15100309

A Polyurethane Electrospun Membrane Loaded with Bismuth Lipophilic Nanoparticles (BisBAL NPs): Proliferation, Bactericidal, and Antitumor Properties, and Effects on MRSA and Human Breast Cancer Cells

Abstract

Bibliographical note

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UN SDGs

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