Mathematical model simulations may assist in the selection of mechanical ventilator settings. Previously, simulations have been limited to control ventilator modes, as these models lacked representation of respiratory control. This paper presents integration of a chemoreflex respiratory control model with models describing: ventilation and pulmonary gas exchange; oxygenation and acid-base status of blood; circulation; interstitial fluid and tissue buffering; and metabolism. A sensitivity analysis showed that typical response to changing ventilator settings can be described by base excess (BE), production of CO2 (VCO2), and model parameters describing central chemoreceptor behavior. Since BE and VCO2, can be routinely measured, changes in ventilator support may therefore be used to identify patient-specific chemoreceptor drive, enabling patient-specific predictions of the response to changes in mechanical ventilation.
|Title of host publication||19th IFAC World Congress IFAC 2014, Proceedings|
|Editors||Edward Boje, Xiaohua Xia|
|Number of pages||6|
|Publication status||Published - 1 Jan 2014|
|Event||19th IFAC World Congress on International Federation of Automatic Control, IFAC 2014 - Cape Town, South Africa|
Duration: 24 Aug 2014 → 29 Aug 2014
|Name||IFAC Proceedings Volumes (IFAC-PapersOnline)|
|Conference||19th IFAC World Congress on International Federation of Automatic Control, IFAC 2014|
|Period||24/8/14 → 29/8/14|
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Copyright 2020 Elsevier B.V., All rights reserved.
All Science Journal Classification (ASJC) codes
- Control and Systems Engineering