A mathematical model for simulating respiratory control during support ventilation modes

Sebastian Larraza; Nilanjan Dey; Dan S. Karbing; Morten Nygaard; Robert Winding; Stephen E. Rees

doi:10.3182/20140824-6-za-1003.01024

A mathematical model for simulating respiratory control during support ventilation modes

Sebastian Larraza, Nilanjan Dey, Dan S. Karbing, Morten Nygaard, Robert Winding, Stephen E. Rees

Departamento de Ciencias Clínicas

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Citations (Scopus)

Abstract

Mathematical model simulations may assist in the selection of mechanical ventilator settings. Previously, simulations have been limited to control ventilator modes, as these models lacked representation of respiratory control. This paper presents integration of a chemoreflex respiratory control model with models describing: ventilation and pulmonary gas exchange; oxygenation and acid-base status of blood; circulation; interstitial fluid and tissue buffering; and metabolism. A sensitivity analysis showed that typical response to changing ventilator settings can be described by base excess (BE), production of CO₂ (VCO₂), and model parameters describing central chemoreceptor behavior. Since BE and VCO₂, can be routinely measured, changes in ventilator support may therefore be used to identify patient-specific chemoreceptor drive, enabling patient-specific predictions of the response to changes in mechanical ventilation.

Original language	English
Title of host publication	19th IFAC World Congress IFAC 2014, Proceedings
Editors	Edward Boje, Xiaohua Xia
Publisher	IFAC Secretariat
Pages	8433-8438
Number of pages	6
ISBN (Electronic)	9783902823625
ISBN (Print)	9783902823625
DOIs	https://doi.org/10.3182/20140824-6-za-1003.01024
Publication status	Published - 1 Jan 2014
Event	19th IFAC World Congress on International Federation of Automatic Control, IFAC 2014 - Cape Town, South Africa Duration: 24 Aug 2014 → 29 Aug 2014

Publication series

Name	IFAC Proceedings Volumes (IFAC-PapersOnline)
Volume	19
ISSN (Print)	1474-6670

Conference

Conference	19th IFAC World Congress on International Federation of Automatic Control, IFAC 2014
Country/Territory	South Africa
City	Cape Town
Period	24/8/14 → 29/8/14

Bibliographical note

Publisher Copyright:
© IFAC.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

All Science Journal Classification (ASJC) codes

Control and Systems Engineering

Access to Document

10.3182/20140824-6-za-1003.01024

Cite this

Larraza, S., Dey, N., Karbing, D. S., Nygaard, M., Winding, R., & Rees, S. E. (2014). A mathematical model for simulating respiratory control during support ventilation modes. In E. Boje, & X. Xia (Eds.), 19th IFAC World Congress IFAC 2014, Proceedings (pp. 8433-8438). (IFAC Proceedings Volumes (IFAC-PapersOnline); Vol. 19). IFAC Secretariat. https://doi.org/10.3182/20140824-6-za-1003.01024

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title = "A mathematical model for simulating respiratory control during support ventilation modes",

abstract = "Mathematical model simulations may assist in the selection of mechanical ventilator settings. Previously, simulations have been limited to control ventilator modes, as these models lacked representation of respiratory control. This paper presents integration of a chemoreflex respiratory control model with models describing: ventilation and pulmonary gas exchange; oxygenation and acid-base status of blood; circulation; interstitial fluid and tissue buffering; and metabolism. A sensitivity analysis showed that typical response to changing ventilator settings can be described by base excess (BE), production of CO2 (VCO2), and model parameters describing central chemoreceptor behavior. Since BE and VCO2, can be routinely measured, changes in ventilator support may therefore be used to identify patient-specific chemoreceptor drive, enabling patient-specific predictions of the response to changes in mechanical ventilation.",

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Larraza, S, Dey, N, Karbing, DS, Nygaard, M, Winding, R & Rees, SE 2014, A mathematical model for simulating respiratory control during support ventilation modes. in E Boje & X Xia (eds), 19th IFAC World Congress IFAC 2014, Proceedings. IFAC Proceedings Volumes (IFAC-PapersOnline), vol. 19, IFAC Secretariat, pp. 8433-8438, 19th IFAC World Congress on International Federation of Automatic Control, IFAC 2014, Cape Town, South Africa, 24/8/14. https://doi.org/10.3182/20140824-6-za-1003.01024

A mathematical model for simulating respiratory control during support ventilation modes. / Larraza, Sebastian; Dey, Nilanjan; Karbing, Dan S. et al.
19th IFAC World Congress IFAC 2014, Proceedings. ed. / Edward Boje; Xiaohua Xia. IFAC Secretariat, 2014. p. 8433-8438 (IFAC Proceedings Volumes (IFAC-PapersOnline); Vol. 19).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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A mathematical model for simulating respiratory control during support ventilation modes

Abstract

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