A mathematical model for simulating respiratory control during support ventilation modes

Sebastian Larraza, Nilanjan Dey, Dan S. Karbing, Morten Nygaard, Robert Winding, Stephen E. Rees

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    7 Citations (Scopus)

    Abstract

    Mathematical model simulations may assist in the selection of mechanical ventilator settings. Previously, simulations have been limited to control ventilator modes, as these models lacked representation of respiratory control. This paper presents integration of a chemoreflex respiratory control model with models describing: ventilation and pulmonary gas exchange; oxygenation and acid-base status of blood; circulation; interstitial fluid and tissue buffering; and metabolism. A sensitivity analysis showed that typical response to changing ventilator settings can be described by base excess (BE), production of CO2 (VCO2), and model parameters describing central chemoreceptor behavior. Since BE and VCO2, can be routinely measured, changes in ventilator support may therefore be used to identify patient-specific chemoreceptor drive, enabling patient-specific predictions of the response to changes in mechanical ventilation.

    Original languageEnglish
    Title of host publication19th IFAC World Congress IFAC 2014, Proceedings
    EditorsEdward Boje, Xiaohua Xia
    PublisherIFAC Secretariat
    Pages8433-8438
    Number of pages6
    ISBN (Electronic)9783902823625
    ISBN (Print)9783902823625
    DOIs
    Publication statusPublished - 1 Jan 2014
    Event19th IFAC World Congress on International Federation of Automatic Control, IFAC 2014 - Cape Town, South Africa
    Duration: 24 Aug 201429 Aug 2014

    Publication series

    NameIFAC Proceedings Volumes (IFAC-PapersOnline)
    Volume19
    ISSN (Print)1474-6670

    Conference

    Conference19th IFAC World Congress on International Federation of Automatic Control, IFAC 2014
    Country/TerritorySouth Africa
    CityCape Town
    Period24/8/1429/8/14

    Bibliographical note

    Publisher Copyright:
    © IFAC.

    Copyright:
    Copyright 2020 Elsevier B.V., All rights reserved.

    All Science Journal Classification (ASJC) codes

    • Control and Systems Engineering

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