A mathematical model for simulating respiratory control during support ventilation modes

Sebastian Larraza, Nilanjan Dey, Dan S. Karbing, Morten Nygaard, Robert Winding, Stephen E. Rees

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Mathematical model simulations may assist in the selection of mechanical ventilator settings. Previously, simulations have been limited to control ventilator modes, as these models lacked representation of respiratory control. This paper presents integration of a chemoreflex respiratory control model with models describing: ventilation and pulmonary gas exchange; oxygenation and acid-base status of blood; circulation; interstitial fluid and tissue buffering; and metabolism. A sensitivity analysis showed that typical response to changing ventilator settings can be described by base excess (BE), production of CO2 (VCO2), and model parameters describing central chemoreceptor behavior. Since BE and VCO2, can be routinely measured, changes in ventilator support may therefore be used to identify patient-specific chemoreceptor drive, enabling patient-specific predictions of the response to changes in mechanical ventilation.

Original languageEnglish
Title of host publication19th IFAC World Congress IFAC 2014, Proceedings
EditorsXiaohua Xia, Edward Boje
PublisherIFAC Secretariat
Pages8433-8438
Number of pages6
ISBN (Electronic)9783902823625
Publication statusPublished - 1 Jan 2014
Event19th IFAC World Congress on International Federation of Automatic Control, IFAC 2014 - Cape Town, South Africa
Duration: 24 Aug 201429 Aug 2014

Publication series

NameIFAC Proceedings Volumes (IFAC-PapersOnline)
Volume19
ISSN (Print)1474-6670

Conference

Conference19th IFAC World Congress on International Federation of Automatic Control, IFAC 2014
CountrySouth Africa
CityCape Town
Period24/8/1429/8/14

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All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Cite this

Larraza, S., Dey, N., Karbing, D. S., Nygaard, M., Winding, R., & Rees, S. E. (2014). A mathematical model for simulating respiratory control during support ventilation modes. In X. Xia, & E. Boje (Eds.), 19th IFAC World Congress IFAC 2014, Proceedings (pp. 8433-8438). (IFAC Proceedings Volumes (IFAC-PapersOnline); Vol. 19). IFAC Secretariat.