Abstract
This paper presents a mathematical model-approach to describe and quantify patient-response to changes in ventilator support. The approach accounts for changes in metabolism (V˙O2, V˙CO2) and serial dead space (VD), and integrates six physiological models of: pulmonary gas-exchange; acid-base chemistry of blood, and cerebrospinal fluid; chemoreflex respiratory-drive; ventilation; and degree of patients' respiratory muscle-response.The approach was evaluated with data from 12 patients on volume support ventilation mode. The models were tuned to baseline measurements of respiratory gases, ventilation, arterial acid-base status, and metabolism. Clinical measurements and model simulated values were compared at five ventilator support levels.The models were shown to adequately describe data in all patients (χ2, p>0.2) accounting for changes in V˙CO2, VD and inadequate respiratory muscle-response. F-ratio tests showed that this approach provides a significantly better (p<0.001) description of measured data than: (a) a similar model omitting the degree of respiratory muscle-response; and (b) a model of constant alveolar ventilation. The approach may help predict patients' response to changes in ventilator support at the bedside.
Original language | English |
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Pages (from-to) | 341-349 |
Number of pages | 9 |
Journal | Medical Engineering and Physics |
Volume | 37 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Apr 2015 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2015 IPEM.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
All Science Journal Classification (ASJC) codes
- Biophysics
- Biomedical Engineering