Rafael Baltazar Reyes León Cachón

PhD, Doctor en Ciencias

  • 97 Citations
  • 5 h-Index
20102019
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Research Output 2010 2019

2019

METHOD FOR DETECTING THE POLYMORPHISM GSTM3 A/B IN HUMAN DNA SAMPLES

Leon-Cachon, R. B. R., Moreno Treviño, M. G. & Martínez-Treviño, D. A., 15 Mar 2019, IPC No. MX/a/2017/009634, Instituto Mexicano de la Propiedad Industrial,

Research output: Patent

Patents and inventions
Polymorphism
DNA
Economics
2018

ACE, APOA5, and MTP Gene Polymorphisms Analysis in Relation to Triglyceride and Insulin Levels in Pediatric Patients

Carranza-González, L., León-Cachón, R. B. R., González-Zavala, M. A., Ríos-Ibarra, C., Morlett-Chávez, J., Sánchez-Domínguez, C., Cepeda-Nieto, A. & Salinas-Santander, M., 1 Feb 2018, In : Archives of Medical Research. 49, 2, p. 94-100 7 p.

Research output: Contribution to journalArticle

Triglycerides
Insulin
Pediatrics
Phenotype
Population

A novel method to detect the Mexican founder mutation BRCA1 ex9-12del associated with breast and ovarian cancer using quantitative polymerase chain reaction and TaqMan probes

Martínez-Treviño, D. A., León-Cachón, R. B. R., Villarreal-Garza, C., Méndez, D. A. Y., Aguilar-Martínez, E. & Barrera-Saldaña, H. A., 1 Aug 2018, In : Molecular Medicine Reports. 18, 2, p. 1531-1537 7 p.

Research output: Contribution to journalArticle

Polymerase chain reaction
Ovarian Neoplasms
Introns
Exons
Breast Neoplasms
1 Citation (Scopus)

Genotypic and phenotypic factors influencing drug response in Mexican patients with type 2 Diabetes Mellitus

Sanchez-Ibarra, H. E., Reyes-Cortes, L. M., Jiang, X. L., Luna-Aguirre, C. M., Aguirre-Trevino, D., Morales-Alvarado, I. A., Leon-Cachon, R. B., Lavalle-Gonzalez, F., Morcos, F. & Barrera-Saldaña, H. A., 6 Apr 2018, In : Frontiers in Pharmacology. 9, APR, 320.

Research output: Contribution to journalArticle

Hypoglycemic Agents
Type 2 Diabetes Mellitus
Pharmaceutical Preparations
Genotype
Biguanides
1 Citation (Scopus)

Infrared meibography and molecular assessment of p63 gene mutations in a Mexican patient with EEC syndrome

Garza-Leon, M., León-Cachón, R. B. R., Villafuerte-de la Cruz, R. & Martínez-Treviño, D. A., 1 Nov 2018, In : Archivos de la Sociedad Espanola de Oftalmologia. 93, 11, p. 562-566 5 p.

Research output: Contribution to journalArticle

Meibomian Glands
Mutation
Eyelids
Genes
Anodontia

Manual de prácticas del laboratorio de biología celular y genética molecular: Manual de prácticas

Translated title of the contribution: Manual of practices of the laboratory of cellular biology and molecular genetics: Manual of practicesMartínez-Treviño, D. A., Camacho Moll, M. E., Huerta Oros, J., Aguirre-Garza, M., Moreno Treviño, M. G., Leon-Cachon, R. B. R., Garza Ruizesparza, R. I. & García Tovar, L. E., 1 Feb 2018, 1 ed. San Pedro Garza García: Manual Moderno. 130 p.

Research output: Book/ReportBook

Cytology
Blood Group Antigens
Macromolecules
DNA
Blood
2017

DESIGN AND USE OF PROBES FOR THE DETECTION AND DIAGNOSIS OF THE RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA

Leon-Cachon, R. B. R., Moreno Treviño, M. G. & Salas Alanis, J. C., 7 Apr 2017, IPC No. MX/a/2015/013331, Instituto Mexicano de la Propiedad Industrial,

Research output: Patent

Patents and inventions
Genes
1 Citation (Scopus)

Effect of AGTR1 and BDKRB2 gene polymorphisms on atorvastatin metabolism in a Mexican population

Herrera-González, S., Martínez-Treviño, D. A., Aguirre-Garza, M., Gómez-Silva, M., Barrera-Saldaña, H. A. & León-Cachón, R. B. R., 1 Dec 2017, In : Biomedical Reports. p. 579-584 6 p.

Research output: Contribution to journalArticle

Polymorphism
Metabolism
Pharmacokinetics
Genes
Phenotype
5 Citations (Scopus)

Molecular identification of unusual Mycetoma agents isolated from patients in Venezuela

Rojas, O. C., León-Cachón, R. B. R., Moreno-Treviño, M. & González, G. M., 1 Feb 2017, In : Mycoses. 60, 2, p. 129-135 7 p.

Research output: Contribution to journalArticle

Mycetoma
Venezuela
Proxy
Nocardia
Madurella
8 Citations (Scopus)

Prediction of atorvastatin plasmatic concentrations in healthy volunteers using integrated pharmacogenetics sequencing

Cruz-Correa, O. F., León-Cachón, R. B. R., Barrera-Saldaña, H. A. & Soberón, X., 1 Jan 2017, In : Pharmacogenomics. p. 121-131 11 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Area Under Curve
Healthy Volunteers
Genes
Medicine
2016
14 Citations (Scopus)

A pharmacogenetic pilot study reveals MTHFR, DRD3, and MDR1 polymorphisms as biomarker candidates for slow atorvastatin metabolizers

León-Cachón, R. B. R., Ascacio-Martínez, J. A., Gamino-Peña, M. E., Cerda-Flores, R. M., Meester, I., Gallardo-Blanco, H. L., Gómez-Silva, M., Piñeyro-Garza, E. & Barrera-Saldaña, H. A., 8 Feb 2016, In : BMC Cancer. 16, 1, 74.

Research output: Contribution to journalArticle

Biomarkers
Pharmacokinetics
Phenotype
Healthy Volunteers
Population
1 Citation (Scopus)

Assessment of biochemical parameters and characterization of TNFα -308G/A and PTPN22 +1858c/T gene polymorphisms in the risk of obesity in adolescents

Salinas-Santander, M. A., León-Cachón, R. B., Cepeda-Nieto, A. C., Sánchez-Domínguez, C. N., González-Zavala, M. A., Gallardo-Blanco, H. L., Esparza-González, S. C. & González-Madrazo, M. Á., 1 Jan 2016, In : Biomedical Reports. 4, 1, p. 107-111 5 p.

Research output: Contribution to journalArticle

Pediatric Obesity
Polymorphism
Tumor Necrosis Factor-alpha
Genes
Obesity

Efectos adversos de los antibióticos sobre la mitocondria y su asociación con variantes genéticas del ADN mitocondrial en población mexicana

Translated title of the contribution: Adverse effects of antibiotics on the mitochondria and their association with genetic variants of mitochondrial DNA in Mexican populationHerrera-González, S., García Tovar, L. E., Martínez-Treviño, D. A., Rojas, O. C. & León Cachón, R. B. R., 6 May 2016, In : Revista Mexicana de Ciencias Farmaceuticas. 46, 4, p. 15-24 10 p.

Research output: Contribution to journalArticle

Open Access
Mitochondrial DNA
Mitochondria
Anti-Bacterial Agents
Population
origen
3 Citations (Scopus)

Rapid Detection of the GSTM3 A/B Polymorphism Using Real-time PCR with TaqMan® Probes

Martínez-Treviño, D. A., Moreno-Treviño, M. G., Salinas-Santander, M., Wohn, L., Herrera-González, S., Aguirre-Garza, M., Rojas, O. C. & León-Cachón, R. B. R., 1 Feb 2016, In : Archives of Medical Research. 47, 2, p. 142-145 4 p.

Research output: Contribution to journalArticle

Real-Time Polymerase Chain Reaction
Glutathione Transferase
Phase II Metabolic Detoxication
Genotyping Techniques
Xenobiotics
2015
3 Citations (Scopus)

Application of genomic technologies in clinical pharmacology research

Leon-Cachon, R. B. R., Ascacio-Martinez, J. A. I., Gomez-Silva, M., Pilieyro-Garza, E., Gonzalez-Gonzalez, J. G., Pogue, G., Simôn-Buela, L. & Barrera-Saldaea, H. A., 1 Jan 2015, In : Revista de Investigacion Clinica. 67, 4, p. 212-218 7 p.

Research output: Contribution to journalReview article

Clinical Pharmacology
Technology
Research
Pharmaceutical Preparations
Precision Medicine
5 Citations (Scopus)

Phenotypic and molecular identification of Fonsecaea pedrosoi strains isolated from chromoblastomycosis patients in Mexico and Venezuela

Carolina Rojas, O., León-Cachón, R. B. R., Pérez-Maya, A. A., Aguirre-Garza, M., Moreno-Treviño, M. G. & González, G. M., 1 Jan 2015, In : Mycoses. 58, 5, p. 267-272 6 p.

Research output: Contribution to journalArticle

Chromoblastomycosis
Venezuela
Mexico
terbinafine
Ribosomal Spacer DNA
2014
2 Citations (Scopus)

Real-time PCR Detection of the Recessive Dystrophic Epidermolysis Bullosa-associated c.2470insG Mutation in Unrelated Mexican Families

Moreno-Treviño, M. G., León-Cachón, R. B. R., González-Salazar, F., Aguirre-Garza, M., Cerda-Flores, R. M., Meester, I. & Salas-Alanis, J. C., 1 Jan 2014, In : Archives of Medical Research. 45, 7, p. 596-599 4 p.

Research output: Contribution to journalArticle

Epidermolysis Bullosa Dystrophica
Real-Time Polymerase Chain Reaction
Mutation
Genotype
High-Throughput Screening Assays

Relationship of Mitochondrial DNA Haplogroups with Complex Diseases

Urzúa Traslaviña, C. G., Moreno Treviño, M. G., Martínez-Treviño, D. A., Barrera-Saldaña, H. & León Cachón, R. B. R., 16 Dec 2014, In : Journal of Genetics and Genome Research. 1, 2, p. 1-5 6 p.

Research output: Contribution to journalArticle

Open Access
Mitochondrial DNA
Mitochondria
Metabolic Diseases
Eukaryota
Research
2012
2 Citations (Scopus)

Evaluating SKI as a candidate gene for non-syndromic cleft lip with or without cleft palate

Mangold, E., Reutter, H., León-Cachón, R. B. R., Ludwig, K. U., Herms, S., Chacón-Camacho, Ó., Ortiz-López, R., Paredes-Zenteno, M., Arizpe-Cantú, A., Muñoz-Jiménez, S. G., Nowak, S., Kramer, F. J., Wienker, T. F., Nöthen, M. M., Knapp, M. & Rojas-Martínez, A., 1 Oct 2012, In : European Journal of Oral Sciences. p. 373-377 5 p.

Research output: Contribution to journalArticle

Cleft Lip
Cleft Palate
Genes
Population
Philippines
10 Citations (Scopus)

Individual response to drug therapy: Bases and study approaches

Leoń-Cachón, R. B. R., Ascacio-Martínez, J. Á. & Barrera-Saldaña, H. A., 1 Jul 2012, In : Revista de Investigacion Clinica. p. 364-376 13 p.

Research output: Contribution to journalLiterature review

Drug Therapy
Drug Monitoring
Liver Microsomes
Genetic Polymorphisms
Recombinant Proteins
2010
41 Citations (Scopus)

Genetic risk factors for nonsyndromic cleft lip with or without cleft palate in a mesoamerican population: Evidence for IRF6 and variants at 8q24 and 10q25

Rojas-Martinez, A., Reutter, H., Chacon-Camacho, O., Leon-Cachon, R. B. R., Munoz-Jimenez, S. G., Nowak, S., Becker, J., Herberz, R., Ludwig, K. U., Paredes-Zenteno, M., Arizpe-Cantú, A., Raeder, S., Herms, S., Ortiz-Lopez, R., Knapp, M., Hoffmann, P., Nöthen, M. M. & Mangold, E., 1 Jan 2010, In : Birth Defects Research Part A - Clinical and Molecular Teratology. p. 535-537 3 p.

Research output: Contribution to journalArticle

Cleft Lip
Cleft Palate
Population
Genome-Wide Association Study
Homozygote